The best Ryze combo is to start with R then lead into W then just use Q in between every W and E
Here is my config to simulate this combo order:
[RYZE] RyzeHarassCombo_QInHarassOrder=2 RyzeHarassCombo_QShowCastRange=0 RyzeHarassCombo_QDontContinueIfOutOfRange=0 RyzeHarassCombo_QUseAABeforeCastIfInRange=1 RyzeHarassCombo_WInHarassOrder=3 RyzeHarassCombo_WShowCastRange=0 RyzeHarassCombo_WDontContinueIfOutOfRange=0 RyzeHarassCombo_WUseAABeforeCastIfInRange=1 RyzeHarassCombo_EInHarassOrder=4 RyzeHarassCombo_EShowCastRange=0 RyzeHarassCombo_EDontContinueIfOutOfRange=0 RyzeHarassCombo_EUseAABeforeCastIfInRange=1 RyzeHarassCombo_RInHarassOrder=1 RyzeHarassCombo_RShowCastRange=0 RyzeHarassCombo_RDontContinueIfOutOfRange=0 RyzeHarassCombo_RUseAABeforeCastIfInRange=1 RyzeHarassCombo_HarassHotkey=32 RyzeHarassCombo_EnableHarassCombo=1 RyzeHarassCombo_CirclesTransparency=144 RyzeHarassCombo_UseItemsInHarass=1 RyzeHarassCombo_LastHitMinionsWhileHarass=1 RyzeHarassCombo_EnableMinionsLastHit=1 RyzeHarassCombo_LastHitHotkey=88 RyzeHarassCombo_LastHitMinionMarker=1 RyzeHarassCombo_EnableLaneClear=1 RyzeHarassCombo_LaneClearHotkey=86 RyzeHarassCombo_DrawMinionsNearKill=1